Well said by many already. A lot of folks have the misconception that cartridge cases are "fill" of powder - which is wrong for smokeless powder in a lot of cases. Black powder cartridges (as muzzleloading rifles, pistols, shotguns) can have no air space between the powder and ball/load - if there is - the results are not nice.
As already mentioned, different smokeless powders have different "make up" - some are "ball", some "stick", some "flake" etc. The "grain weight" of a smokeless powder charge will vary depending on the type/make up of the powder and the "volume" of the load will as well. i.e. - some powders are more "dense" and others are more "fluffy".
I load mainly 9mm and a lot of 38 special. My powder of preference is Bulls Eye. My charges can vary from 2.7 grains of BE for my wad cutter loads to 3.2 or a little more for my round nose bullet loads (I only shoot cast lead). "Volume wise" - those charges take up very little room in a 38 special casing so a double or even a triple charge could be possible if you aren't paying attention. That mistake could cost you a good revolver and perhaps some fingers. A different powder, such as Trail Boss which is "fluffy" would take up the majority of the room in a casing so it would be awful hard to "double charge" and not catch.
Reloading is an interesting and rewarding hobby - but you need to keep your wits about you when doing it and always double check yourself. I load with a 4 die Lee set of dies on a 4 hole Lee turret. I have a Lee Perfect Powder Measure mounted to my expander/powder thru die. After the casing is in the die and expanded, I trip the powder measure and dump a charge in before indexing to the seating die. I find that measure to be very accurate and consistent with Bulls Eye. I have never used it with other powders. I just keep on my toes and when loading a cartridge, make sure that I only introduce one load in to the casing. If I get interrupted for some reason, I stop, remove the casing and if charged or not, dump it back in to the hopper and start over. Every tenth cartridge, I charge it, remove it and dump the load in a scale to make sure everything is consistent.