Carry what you're comfortable with and can shoot accurately.
When we talk J frame Smith's, you have a choice of a 7 shot .22 Mag or 8 shot .22 LR. For 22 Mag, it's the 351 C (internal hammer) or the 351 PD (exposed hammer).
With either of these options, the name of the game is reliability and penetration. The new Federal Punch in .22 LR seems to be getting at least 12 inches of penetration out of these 2" barrels (FBI minimum recommendation). The .22 Mags seem to do a little better.
.22 LR hollow points that actually expand out of these barrels don't meet the 12-inch minimum in penetration. And .22 Mags may or may not meet the minimum if it does expand.
As far as reliability, I've got an 8 shot 43C (.22 LR). I've ran 8 different loads through it and only had one failure to fire. And it was the cartridge. I've had no issue using the Federal Punch. And unlike auto's, you can just keep pulling the trigger until your gun fires. No jam to clear.
I don't foresee a scenario where my 43C is my only carry gun (maybe as a back-up), but it could happen. And it's 8 no recoil rounds if I need it (.22 Mag does have some recoil). This gun is also extremely lightweight even when loaded. I don't find my trigger pull all that bad on mine either.
But only you can decide if this is the right choice for you.
Here's the Lucky Gunners ballistics with .22 mag.
https://www.luckygunner.com/labs/pocket-pistol-caliber-gel-test-results/#22Mag