Everybody has got to know their limitations!!! If you don't carry with a chambered round, you might as well not carry. If you get into a situation where you need to pull your pistol for self defense you are not going to ask the THUGS to wait while you put a round in the chamber. You might have tobe fightning someone off of you or running and taking cover. Also it takes 2 hands to safely chamber a round and you want to be pointing the pistol in a safe direction while chambering a round. Get the BodyGuard with the manuel safety but PLEASE DON'T BE CHAMBERING A ROUND WHEN YOU NEED IT FOR SELF DEFENSE AND SHOOT A BYSTANDER!!!!!!!!!!!!!!!!!If you carry with no round in the chamber (like Honest Outlaw does), the answer is yes. If you want a round in the chamber, you will want a pocket holster (which I use). In that case, the answer is "how tight are your jeans?"