PLG I wouldn't want to put heat to it as that will expand the shank into the nut that is welded to the barrel making it tighter. It's not like your trying to take out a rusted manifold bolt. Because of the frame you can't put heat to the nut.
I would try a good quality hex wrench first. If that fails get it off to Smith&Wesson.
The idea of putting heat to the screw isn't the same as taking off a rusty manifold. The reason for the heat is to break the bond of factory applied thread sealer, and is common practice for removing screws held in place with Lok-tite type products. In many cases, a soldering iron works great for this process. You aren't trying to get the screw red hot, just warm enough to break the sealant's bond.
I normally buy a parts kit for new guns. I would like to get a few barrel screws, springs and pins. I also would like to get a spare threaded barrel. Can't find the parts for the ,22 Victory on Brownells or midway. Can't find anything on the S&W site. What do you do if you loose a screw while cleaning.
Everyone talks about the screw, but no one talks about the Allen wrench.
The one furnished by S&W is too soft and flexes. I used my Eklind heat treated Allen wrench, and it was stiff enough to get the job done. Add VC-3 vibration blocker on the thread, and all is good. No problems after thousands of rounds.
Taking my wife's gun down was hard, impossible with the supplied Allen.Went down to the garage and got a good Allen and even that would not budge the screw. Got a 10'' crescent wrench and put that on the Allen. That finely got it to move. I see they call for 40 inch pounds of force, that screw must have been set to 40 foot pounds. Put it back together just by "feel" and so far (300 rounds) it has not loosened up!
I just purchased the Victory and decided to clean it prior to shooting it. I have also snapped an allen wrench (ball type with a handle) and stripped out the head. I even tried an easy out with a vise grip and have had no luck. Very disappointed. I sent S&W an email and waiting for their response. Makes me wish I had bought Browning or Ruger.
Penetrating oil typically won't do much for thread locking compound. Try heating it with a soldering iron. Heat will cause the thread lock compound to soften up.